Results From Impact Evaluations of Irs and Pbo Itns: Ethiopia and Sierra Leone

Results from impact evaluations of IRS and PBO ITNs: Ethiopia and Sierra Leone Emily Hilton 15th April 2024Context • With an increasing number of vector control tools available for use alone or in combination, national malaria programs (NMPs) need timely, local evidence to guide vector control product choice and deployment decisions. • With support from PMI Evolve, NMPs in Ethiopia and [...] Epidemiological outcomes Entomological outcomes Primary outcom e Routinely-reported confirmed malaria cases (all-ages) Vector density per trap; indoor resting density Study period Sept-Dec, 2019-2022 Sept-Dec, 2021-2022 Modelin g approac h Negative binomial mixed effects models Negative binomial mixed effects models Control variable s Intervention arm, time since intervent [...] pyrethroid ITNs IRS IRS Epidemiological study period Entomological study periodETHIOPIA | Results 4 Overall pre- vs. post- intervention ↓ 55.9% * (-73.0%, -32.5%) Year 2 vs. Year 1 post- intervention ↑ 98.1% * (49.5%, 167.3%) Overall pre- vs. post- intervention ↓ 53.6% * (-72.9%, -29.8%) Year 2 vs. Year 1 post- intervention ↓ 5.9% (-34.3%, 47.2%) No significant differenc [...] There was no significant overall difference in impact between deploying PBO ITNs alone compared to alongside annual IRS in Sierra Leone. [...] • Greater declines in relative impact in the PBO ITN only arm in the 3rd year post-ITN distribution suggest co-deployment with IRS may sustain vector control impact as ITN durability declines. Using routine data to estimate intervention impact Bias in malaria incidence estimates based on routine data can arise from changes in care- seeking, differences in access to parasitological diagnosis [...] Davis, Amha Worku, Meshesha Balkew, Peter Mumba, Sheleme Chibsa, Jon Eric Tongren, Gudissa Assefa, Achamyelesh Sisay, Dawit Teshome, Banchamlak Tegegne, Mastewal Worku, Mulat Yimer, Delenasaw Yewhalaw, Isabel Swamidoss, Melissa Yoshimizu, Sarah Zohdy, Jimee Hwang, Wendy Inouye, Aklilu Seyoum, Cecilia Flatley, Emily R. Hilton, Dereje Dengela, Sarah M. Burnett Sierra Leone National Malaria C [...] Galles, Frederick Yamba, Musa Sillah- Kanu, Kevin Opondo, Yemane Yihdego, Evelyne Alyko, David Schnabel, Rebecca Levine, Jenny Carlson Donnelly, Celeste Carr, Kristen George, Tony Hughes, Isabel Swamidoss, Ramlat Jose, Laurent Iyikirenga, Djenam Jacob, Samuel Juana Smith, Ronald Carshon-Marsh, Mac-Abdul Falama, Sarah Burnett 8Thank You! 9