Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement

OBJECTIVE To compare the rate of revision attributed to PJI following primary total knee arthroplasty (TKA) using ALBC vs plain bone cement. [...] CONCLUSIONS AND RELEVANCE In this study, the risk of revision for PJI was similar between ALBC and plain bone cement following primary TKA. [...] Except for the German and Swiss registries, participating registries reported cumulative 1-year revision rates for all causes of 2% or less both for TKA with ALBC and with plain bone cement (eFigure 2 in Supplement 1). [...] The meta-analyses based on Cox regression found that the difference in risk of revision for PJI between primary TKA with ALBC compared with plain bone cement was not statistically significant (Figure 2; eFigures 3-5 in Supplement 1). [...] Discussion To our knowledge, this cohort study has the largest international registry-based meta-analysis performed to date comparing the association of ALBC vs plain bone cement with risk of revision for PJI and all causes following primary TKA. [...] Nevertheless, data from the participating registries provide important and relevant information on risk of revision following primary TKAs using either ALBC or plain bone cement. [...] The projected burden of primary total knee and hip replacement for osteoarthritis in Australia to the year 2030. [...] Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89(4):780-785. doi:10.2106/00004623- 200704000-00012 6. [...] Effectiveness of antibiotics loaded bone cement in primary total knee arthroplasty: a systematic review and meta-analysis. Orthop Traumatol Surg Res. 2022;108(5):103295. [...] Antibiotic bone cement and the incidence of deep infection after total knee arthroplasty.