Ats 2024 Highlights

ATS 2024 Highlights Respiratory Structure and Function Early Career Professionals If you or someone you know would like to be featured as an ATS RSF ECP please email Carolyn Wang (carolyn.wang@hli.ubc.ca ) Get to know members of the RSF Assembly Anusha Mappanasingam, BSc(Hons) (she/her) MSc Candidate Department of Medicine, McMaster University; Firestone Institute for Respiratory Health, St. [...] Sarah Svenningsen, my research focuses on utilizing quantitative non-contrast chest computed tomography to non-invasively assess the pulmonary vasculature in patients with severe asthma. [...] My current focus is on characterizing the pulmonary vasculature in patients with severe asthma and to determine mechanisms behind the differences in vessel volume that are observed. [...] My aspiration is to contribute to research in respirology and play a role in improving pulmonary disease outcomes using an integrated clinical and medical imaging approach. [...] Specifically, I aspire to contribute to research in diagnosis and treatment outcomes in complex airways diseases. What do you find is the major benefit of RSF Assembly Membership? [...] I am grateful for the opportunities and community that RSF Assembly Membership provides. Through the RSF Assembly, I was awarded an ATS Abstract Scholarship to present my research in a Mini- symposium at my first ATS conference in San Diego. [...] mappana@mcmaster.ca X: @MappanaAnusha LinkedIn: www.linkedin.com/in/anusha-a-mappanasingam Please follow us on LinkedIn and X @ATS_RSFATS 2024 Highlights Respiratory Structure and Function Early Career Professionals Objective: In patients with asthma, a smaller relative volume of the peripheral pulmonary vasculature, often referred to as “vascular pruning” and quantified using chest [...] We recently demonstrated that interleukin-4-receptor antagonism with dupilumab reduces airway mucus and consequently improves airflow in patients with asthma.2 Here we examined the effect of dupilumab on pulmonary vascular volumes assessed by quantitative CT in adults with moderate-to-severe asthma Methods: This retrospective analysis included 26 adults with uncontrolled moderate-to-severe asth [...] Conclusion: In patients with moderate-to-severe asthma, interleukin-4-receptor antagonism with dupilumab caused a redistribution of pulmonary blood volume towards smaller vessels, and this shift in blood volume was associated with improved patient reported outcomes. Ongoing work is aimed at investigating the mechanism behind this improvement. [...] Effect of Dupilumab on Pulmonary Vascular Volume in Patients with Moderate-to-Severe Asthma Please follow us on LinkedIn and X @ATS_RSF