Rosemary Lees, VCWG April 2024 Indications of differential efficacy of chlorfenapyr-based ITNs between sites2 Pyrethroid-chlorfenapyr nets working well – but not equally well everywhere? [...] The evidence for an epidemiological impact of IG2s is strong But there are indications that the benefits over pyrethroid- only nets may be less pronounced in some areas, correlating with high pyrethroid resistance intensity3 Evidence of differential performance between sites Experimental hut trial results suggest that the nets may be more effective in some sites than others, even across a [...] It’s possible the differences in results are due to methodological differences Reducing variability is essential for collecting more robust entomological data Need to interrogate and improve the testing methodology for chlorfenapyr and chlorfenapyr-based products Photo courtesy of Anna Trett7 Could insecticide resistance be the explanation? [...] Performance of dual AI ITNs may be undermined by resistance to one or more of the active ingredients in the nets and/or the interaction between insecticides There are reports of <98% mortality in a bottle bioassay for chlorfenapyr The WHO protocol for testing for chlorfenapyr contains specific instructions in testing method: - Including a susceptible strain to confirm testing conditions
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