Multiple first-line therapies as part of the response to antimalarial drug resistance: an implementation guide

Table of Contents

• Multiple first-line therapies as part of the response to antimalarial drug resistance 1
• Multiple first-line therapies as part of the response to antimalarial drug resistance 3
• Acknowledgements v 5
• Abbreviations vi 5
• Executive summary vii 5
• 1. Background 1 5
• 2. Multiple first-line therapies 10 5
• 3. Implementation of multiple first-line therapies 14 5
• 4. Recommendations for future research 18 5
• References 19 5
• Annex 1. Resources 20 5
• Annex 2. Implications for national policy and implementation of multiple first-line therapies 21 5
• Acknowledgements 7
• Abbreviations 8
• Executive summary 9
• Definition of multiple first-line therapies 11
• Summary conclusions on multiple first-line therapies implementation 13
• 1. Background 15
• 1.1 Update on the status of resistance and the 16
• 1.2 WHO recommendation and guidance on national antimalarial policies and treatment guidelines 17
• 1.3 Overview of case management at national level 19
• 1.4 Availability of antimalarials in the private sector 22
• 2. Multiple first-line therapies 24
• 2.1 Evidence from mathematical modelling 24
• 2.2 Empirical evidence 26
• 2.3 Multiple first-line therapies definition objectives and components 27
• Key concepts 28
• 3. Implementation of multiple first-line therapies 28
• 3.1 Experience from other WHO programmes 28
• 3.2 Guidance for the effective implementation of multiple first- line therapies 29
• 4. Recommendations for future research 32
• References 33
• Annex 1. Resources 34
• Annex 2. Implications for national policy and implementation of multiple first-line 35